| Oakessentials oakessentials.com | 14 | Health & Fitness |
| Oasisofhope oasisofhope.com | 1 | News |
| Observe observe.ai | 2 | Technology |
| Ocampo Capital ocampocapital.com | 1 | Business |
| Oddayaus gooddayaus.com | 1 | Comedy |
| Odgirlrx goodgirlrx.com | 2 | Society & Culture |
| Odoo odoo.com | 3 | Sports |
| Odranchers goodranchers.com | 4 | News |
| Odsc odsc.ai | 1 | Technology |
| Odwipes goodwipes.com | 1 | Comedy |
| OFP Farms ofpfarms.com | 1 | News |
| Ogee ogee.com | 3 | Business |
| Olipop drinkolipop.com | 2 | Health & Fitness |
| Olive App oliveapp.com | 1 | Society & Culture |
| Ollie ollie.com | 8 | TV & Film |
| Omaha Steaks omahasteaks.com | 6 | Sports |
| OmneDiem omnediem.com | 1 | Health & Fitness |
| Omnibioticlife omnibioticlife.com | 2 | Education |
| ONE BONE onebone.com | 1 | Sports |
| Onedevice theonedevice.com | 1 | Health & Fitness |
| OneSkin oneskin.co | 57 | Health & Fitness |
| Onxmaps onxmaps.com | 1 | Science |
| Opencase theopencase.com | 1 | Technology |
| Opendoorfa opendoorfa.com | 1 | Sports |
| Optimove optimove.com | 1 | Business |
| Organifi organifi.com | 3 | Health & Fitness |
| OriginHQ originhq.com | 5 | Technology |
| Orion Sleep orionsleep.com | 4 | Health & Fitness |
| Oseamalibu oseamalibu.com | 20 | Health & Fitness |
| OurFamilyWizard ourfamilywizard.com | 1 | Health & Fitness |
| OutSystems outsystems.com | 4 | Technology |
| Overthemoon overthemoon.com | 2 | Comedy |
| Oxfordhealthspan oxfordhealthspan.com | 2 | Health & Fitness |
| Ozlosleep ozlosleep.com | 1 | Health & Fitness |